Abstract Implants are used to repair human tissues or organs and restore their functions, including artificial joints, bone fixation devices, other orthopedic implants, and vascular interventional devices. Personalized and biodegradable implants are an irresistible trend in the clinic for implantable and interventional medical devices. Biomechanics play a vital role in the innovation of implants. Biodegradable implants have advantages of avoiding long-term complications, i.e., bone stress shielding, restenosis, thrombosis, and secondary surgery. The development of 3D printing technology provides possibility for the innovative design & manufacture of personalized biodegradable implants, which can adapt to the individualization of patients. However, there are still several challenges such as the interaction between the implant and its surrounding tissues, the coordination of structural strength of implants and its degradation, the topological microstructure of implant and its fatigue properties, reliability, and safety. More and more researchers focused on exploring the innovative design, manufacture, and evaluation technology of implants based on in vivo or in vitro tests given biomechanics and mechanobiology. Some critical progress in basic research and innovation technology in related fields was achieved, which provided solid theoretical support for the innovative design of personalized biodegradable implantable and interventional medical devices and their clinical applications.